Emergence of bla OXA-1- and mph(A)-Producing Vibrio furnissii Isolated from Hospital Sewage.

Cephalosporins and azithromycin are clinical antibiotics used to treat infections. Co-resistance to cephalosporins and azithromycin has been observed in some Enterobacterales, but it has only rarely been reported in Vibrio species. In this study, we isolated a cephalosporin- and azithromycin-resistant V. furnissii strain, VFN3, from hospital sewage. Whole-genome sequencing results showed that the strain VFN3 possesses an IncA/C2 plasmid, pVFN3-blaOXA-193K. This conjugative plasmid carries several clinically relevant drug resistance genes, including mph(A) and bla OXA-1. We also found that in the strain VFN3, mph(A) and bla OXA-1 are surrounded by insertion sequences and class I integrons, respectively. These data suggest that mobile elements mediate the transfer of mph(A) and bla OXA-1. This is the first reported Vibrio species that possesses an mph(A)- and bla OXA-1-bearing conjugative plasmid. The emergence of this conjugative multi-drug-resistance plasmid is of great concern to public health. © 2022 Mo et al.

Citation

Haishan Mo, Xu Lin, Ming Liu, Hui Liang. Emergence of bla OXA-1- and mph(A)-Producing Vibrio furnissii Isolated from Hospital Sewage. Infection and drug resistance. 2022;15:3173-3177

PMID: 35754787

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