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Drug resistance to chemotherapy and molecularly targeted therapies is a current challenge in cancer treatments. The underlying mechanisms of resistance to cytotoxic chemotherapeutics and to drugs that target a specific molecule are not understood completely. In recent years, emerging evidence has frequently suggested that the dysregulation of deubiquitinating enzymes (DUBs) plays important roles in the development of drug resistance. We focus on the molecular mechanisms through which DUBs enable cancer cells to escape cell death and survive when exposed to a variety of anti-cancer drugs. Furthermore, this review summarizes the potential application of DUB inhibitors in combination therapies to overcome drug resistance. Copyright © 2022 Elsevier Ltd. All rights reserved.


Fujing Ge, Yuekang Li, Tao Yuan, Yulian Wu, Qiaojun He, Bo Yang, Hong Zhu. Deubiquitinating enzymes: Promising targets for drug resistance. Drug discovery today. 2022 Sep;27(9):2603-2613

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PMID: 35760282

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