Micromonospora: A Prolific Source of Bioactive Secondary Metabolites with Therapeutic Potential.

Micromonospora, one of the most important actinomycetes genera, is well-known as the treasure trove of bioactive secondary metabolites (SMs). Herein, together with an in-depth genomic analysis of the reported Micromonospora strains, all SMs from this genus are comprehensively summarized, containing structural features, bioactive properties, and mode of actions as well as their biosynthetic and chemical synthesis pathways. The perspective enables a detailed view of Micromonospora-derived SMs, which will enrich the chemical diversity of natural products and inspire new drug discovery in the pharmaceutical industry.

Citation

Suqi Yan, Mingyuan Zeng, Hong Wang, Huawei Zhang. Micromonospora: A Prolific Source of Bioactive Secondary Metabolites with Therapeutic Potential. Journal of medicinal chemistry. 2022 Jul 14;65(13):8735-8771

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PMID: 35766919

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