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Chronic Atrophic Gastritis (CAG) is a precancerous condition for gastric cancer (GC) as single risk factor, being a consequence of a previous Helicobacter pylori (Hp) infection or based on autoimmune mechanisms. Achlorhydria plays an important role towards the formation of a class I carcinogen, acetaldehyde, after food intake. L-cysteine has been claimed to be able to bind in a covalent way acetaldehyde when administered at means. In this study we enrolled two CAG groups of patients, one treated whit 300 mg/daily of L-cysteine for one year, the other one untreated. We assessed gastric function lasting the one year follow-up by using non invasive surrogates, i.e. Pepsinogen I (PGI) and gastrin 17 (G17). In the group of 77 CAG on therapy we found a statistically significative increase in PGI values and a decrease in G17 levels, in comparison with unchanged values in control group. L-cysteine seems able to provide a recovery in gastric function when administered in CAG patients and could be proposed as a possible therapy in such patients.


Pellegrino Crafa, Francesco Di Mario, Simone Grillo, Stefano Landi, Marilisa Franceschi, Kryssia Rodriguez-Castro, Antonio Tursi, Giovanni Brandimarte, Lorella Franzoni. Recovery of gastric function in patients affected by chronic atrophic gastritis using l-cysteine (AcetiumĀ®): one year survey in comparison with a control group. Acta bio-medica : Atenei Parmensis. 2022 Jul 01;93(3):e2022184

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PMID: 35775759

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