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The Reinforcement Sensitivity Theory (RST) explains a variety of reward-motivated behaviors as the result of the activation of biologically-based systems. Inspired by the influences of parental bonding and opioid peptide on reward system, we investigated the contributions of parental bonding and mu-opioid receptor gene (OPRM1) towards motivation systems (i.e., the BAS, BIS-anxiety, and FFFS-fear). Results indicated that (1) parental care was negatively related to FFFS-fear, but parental overprotection was positively related to both FFFS-fear and BIS-anxiety; (2) parental care significantly interacted with OPRM1 rs1799971 in reward responsiveness with diathesis-stress model. Poor parental care reduced reward responsiveness among individuals with the G allele, but not those with the AA genotype. These findings from this study demonstrate a new gene-environment interactive mechanism of the RST. Copyright © 2022 Elsevier Ltd. All rights reserved.


Quanhe Wang, Yuting Yang, Rongjun Yu, Wenping Zhao, Mingyang Wang, Yi Wang, Wenxuan Guo, Linlin He, Pingyuan Gong. The interplay between parental care and OPRM1 in reward responsiveness. Psychoneuroendocrinology. 2022 Sep;143:105845

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PMID: 35779341

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