Glucocerebrosidase variant T369M is not a risk factor for Parkinson's disease in Sweden.

Caroline Ran, Lovisa Brodin, Sandra Gellhaar, Marie Westerlund, Camilla Fardell, Hans Nissbrandt, Peter Söderkvist, Olof Sydow, Ioanna Markaki, Ellen Hertz, Karin Wirdefeldt, Per Svenningsson

Neuroscience letters 2022 Jul 27

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Genetic variants in the Beta-glucocerebrosidase gene (GBA1) is a known risk factor for Parkinson's disease. The GBA1 mutations L444P, N370S and many other have been shown to associate with the disease in populations with diverse background. Some GBA1 polymorphisms have a less pronounced effect, and their pathogenicity has been debated. We have previously found associations with L444P, N370S and E326K and Parkinson's disease in Sweden. In this study we used pyrosequencing to genotype the T369M variant in a large Swedish cohort consisting of 1,131 patients with idiopathic Parkinson's disease, and 1,594 control subjects to evaluate the possibility of this variant conferring an increased risk for Parkinson's disease. The minor allele frequency was 2.15% in patients and 1.76% in controls. Statistical analysis showed that there was no significant difference in allele frequency between patients and control subjects, p-value 0.37, Odds Ratio 1.23 with a 95% confidence interval of 0.82-1.83. Our results suggest that T369M is not a risk factor for Parkinson's disease in the Swedish population. Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.

Citation

Caroline Ran, Lovisa Brodin, Sandra Gellhaar, Marie Westerlund, Camilla Fardell, Hans Nissbrandt, Peter Söderkvist, Olof Sydow, Ioanna Markaki, Ellen Hertz, Karin Wirdefeldt, Per Svenningsson. Glucocerebrosidase variant T369M is not a risk factor for Parkinson's disease in Sweden. Neuroscience letters. 2022 Jul 27;784:136767