Versatile signaling mechanisms of inositol pyrophosphates.

Inositol pyrophosphates (PP-InsPs) constitute a group of highly charged messengers, which regulate central biological processes in health and disease, such as cellular phosphate and general energy homeostasis. Deciphering the molecular mechanisms underlying PP-InsP-mediated signaling remains a challenge due to the unique properties of these molecules, the different modes of action they can access, and a somewhat limited chemical and analytical toolset. Herein, we summarize the most recent mechanistic insights into PP-InsP signaling, which illustrate our progress in connecting mechanism and function of PP-InsPs. Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Citation

Minh Nguyen Trung, David Furkert, Dorothea Fiedler. Versatile signaling mechanisms of inositol pyrophosphates. Current opinion in chemical biology. 2022 Oct;70:102177

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PMID: 35780751

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