Genetic mutation of TRPV2 induces anxiety by decreasing GABA-B R2 expression in hippocampus.

Gaoyan Liu, Yamei Liu, Bowen Niu, Yu Zhou, Qingyu Peng, Jinyu Yan, Yunfei Tang, Fuxue Chen, Feng Li, Shini Feng

Biochemical and biophysical research communications 2022 Sep 10

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Transient receptor potential vanillic acid 2 (TRPV2) are well recognized for their contributions to neuronal development, cardiac function, immunity and cancer. However, the precise roles for this thermo TRPchannels in neurological disorder remain unknown. In this study, we employed the CRISPR/Cas9 system to generate genetic mutations of TRPV2. Genetic mutation of TRPV2 resulted in autistic-like phenotypes in mice accompanied with the disordered electrical signals recorded by multi-channels in vivo. To determine possible molecular mechanisms, western blotting was further used to assess the possible involvement of several autism-related proteins. The significantly decreased expression of the R2 subunit of the GABA-B receptor in the hippocampus was observed. Together, our findings suggest that genetic mutation of TRPV2 induces autism-like behavior, results in decreased expression of the R2 subunit of the GABA-B receptor. Copyright © 2022 Elsevier Inc. All rights reserved.

Citation

Gaoyan Liu, Yamei Liu, Bowen Niu, Yu Zhou, Qingyu Peng, Jinyu Yan, Yunfei Tang, Fuxue Chen, Feng Li, Shini Feng. Genetic mutation of TRPV2 induces anxiety by decreasing GABA-B R2 expression in hippocampus. Biochemical and biophysical research communications. 2022 Sep 10;620:135-142