A new role for ammonia in tumorigenesis?

Hyun Min Lee, Anushka Nayak, Jiyeon Kim

Cell metabolism 2022 Jul 05

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Tumor-supporting roles of ammonia have gained greater appreciation in recent years and normally focus on ammonia's role as a nitrogen source. Recently in Nature Metabolism,Cheng et al. (2022) demonstrate a novel, non-nitrogen, metabolism-related role of ammonia as a key activator for lipogenesis by facilitating SREBP-1 activation. Copyright © 2022 Elsevier Inc. All rights reserved.