Ascorbate-assisted nitric oxide release from photocontrollable nitrosonium ion releasers for potent ex vivo photovasodilation.

Naoya Ieda, Yuka Yoshikawa, Natsumi Tomita, Kei Ohkubo, Yuji Hotta, Mitsuyasu Kawaguchi, Kazunori Kimura, Hidehiko Nakagawa

Chemical communications (Cambridge, England) 2022 Jul 26

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We found that N-nitrosoaminoanisole derivatives tethered to dyes work as photocontrollable nitrosonium cation releasers and are converted to potent nitric oxide releasers in the presence of sodium ascorbate. The N-nitrosoaminoanisole derivative 2 worked as a more potent photovasodilating reagent ex vivo than previously reported nitric oxide releasers.

Citation

Naoya Ieda, Yuka Yoshikawa, Natsumi Tomita, Kei Ohkubo, Yuji Hotta, Mitsuyasu Kawaguchi, Kazunori Kimura, Hidehiko Nakagawa. Ascorbate-assisted nitric oxide release from photocontrollable nitrosonium ion releasers for potent ex vivo photovasodilation. Chemical communications (Cambridge, England). 2022 Jul 26;58(60):8420-8423