Action mechanisms of metallic compounds on Plasmodium spp.

Casarrubias-Tabarez Brenda, Rivera-Fernández Norma, Rojas-Lemus Marcela, López-Valdez Nelly, Fortoul Teresa I

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2022 Sep

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Malaria is a parasitic disease with the highest morbidity and mortality worldwide. Unfortunately, during the last decades, the causal agent, Plasmodium spp., has developed resistance to chloroquine and artemisinin. For this reason, metallic compounds have been proposed as an optional treatment since they have shown a potential antimalarial effect with diverse action mechanisms in the parasite and the host. To show the possible targets of metallic compounds in Plasmodium spp. The metallic compounds are an option attractive to treatment for the malaria, for its low cost and its great activity to reduce parasitemia; however is necessary more studies principally in vivo in order to know the interactions that it can have in an experimental model. Copyright © 2022 Elsevier GmbH. All rights reserved.

Citation

Casarrubias-Tabarez Brenda, Rivera-Fernández Norma, Rojas-Lemus Marcela, López-Valdez Nelly, Fortoul Teresa I. Action mechanisms of metallic compounds on Plasmodium spp. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). 2022 Sep;73:127028