Distinct biochemical properties of the class I histone deacetylase complexes.

Kwangwoon Lee, Samuel D Whedon, Zhipeng A Wang, Philip A Cole

Current opinion in chemical biology 2022 Oct

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Classical histone deacetylases (HDACs) are enzymes that can hydrolytically cleave acetyl-Lys in histones and other proteins and serve as established drug targets in some forms of cancer. Class I HDACs 1-3 typically exist in a range of multiprotein complexes inside cells and show distinct biological functions in modulating gene expression. In recent years, it has become possible to purify and analyze the structure and enzymatic properties of several of these HDAC complexes, including CoREST, MiDAC, NuRD, Sin3, SMRT, MIER, and RERE. Here, we summarize what is experimentally established and/or computationally predicted about the structure of these complexes to describe their particular catalytic activities and site-specificities with modified nucleosome substrates. Copyright © 2022 Elsevier Ltd. All rights reserved.

Citation

Kwangwoon Lee, Samuel D Whedon, Zhipeng A Wang, Philip A Cole. Distinct biochemical properties of the class I histone deacetylase complexes. Current opinion in chemical biology. 2022 Oct;70:102179