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It takes two to tango: Rycals and ATP snuggle up to bind ryanodine receptors.

Raika Pancaroglu, Filip Van Petegem

Structure (London, England : 1993) 2022 Jul 07


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  • atp bind (1)
  • calcium (2)
  • cardiac muscle (1)
  • receptor calcium (2)
  • receptors (2)
  • skeletal muscle (2)
    • Sizes of these terms reflect their relevance to your search.

    In this issue of Structure, Melville and colleagues used cryo-EM to study the binding of ryanodine receptors to Rycals, compounds with the potential to treat skeletal and cardiac muscle disorders. Unexpectedly, they found that Rycal packs against an ATP in a peripheral pocket, which stabilizes the closed channel state. Copyright © 2022 Elsevier Ltd. All rights reserved.

    Citation

    Raika Pancaroglu, Filip Van Petegem. It takes two to tango: Rycals and ATP snuggle up to bind ryanodine receptors. Structure (London, England : 1993). 2022 Jul 07;30(7):919-921

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    PMID: 35803239

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