Enoxaparin Increases D6 Receptor Expression and Restores Cytoskeleton Organization in Trophoblast Cells from Preeclampsia.

Chiara Tersigni, Giuseppe Maulucci, Roberta Castellani, Giada Bianchetti, Marianna Onori, Rita Franco, Greta Barbaro, Marco De Spirito, Antonio Lanzone, Giovanni Scambia, Nicoletta Di Simone

Cells 2022 Jun 27

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D6 is a scavenger receptor for CC chemokines expressed in the human placenta. It prevents excessive leukocyte tissue infiltration by internalizing chemokines through cytoskeleton-dependent intracellular transport. In preeclampsia (PE), the D6 receptor is overexpressed in trophoblast cells, but functionally impaired, due to cytoskeleton destructuring. Low molecular weight heparin (LMWH) represents a potential treatment for PE based on its anti-thrombotic and anti-inflammatory properties. Here, we investigated the effect of enoxaparin on D6 expression, and cytoskeleton organization primary cytotrophoblast cell cultures were obtained from the placentae of women with PE (n = 9) or uncomplicated pregnancy (n = 9). We demonstrated that enoxaparin is able to (i) increase D6 expression, and (ii) improve cytoskeletal fiber alignment in trophoblast cells from PE patients.

Citation

Chiara Tersigni, Giuseppe Maulucci, Roberta Castellani, Giada Bianchetti, Marianna Onori, Rita Franco, Greta Barbaro, Marco De Spirito, Antonio Lanzone, Giovanni Scambia, Nicoletta Di Simone. Enoxaparin Increases D6 Receptor Expression and Restores Cytoskeleton Organization in Trophoblast Cells from Preeclampsia. Cells. 2022 Jun 27;11(13)