Loss of TRIM67 Attenuates the Progress of Obesity-Induced Non-Alcoholic Fatty Liver Disease.

Chao Huang, Xiaoli Wei, Qihui Luo, Yu Xia, Ting Pan, Junbo He, Asad Jahangir, Lanlan Jia, Wentao Liu, Yuanfeng Zou, Lixia Li, Hongrui Guo, Yi Geng, Zhengli Chen

International journal of molecular sciences 2022 Jul 05

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Obesity is considered as a major cause for the development and progress of non-alcoholic fatty liver disease (NAFLD), which is one of the most prevalent chronic liver diseases worldwide. However, molecular mechanisms that implicate in obesity-driven pathophysiology of NAFLD are not well defined. Here, we report a tripartite motif (TRIM) protein family member-TRIM67-that is hardly expressed in liver but is inducible on obese conditions. Enhanced expression of TRIM67 activates hepatic inflammation to disturb lipid metabolic homeostasis and promote the progress of NAFLD induced by obesity, while the deficiency in TRIM67 is protective against these pathophysiological processes. Finally, we show that the important transcription coactivator PGC-1α implicates in the response of hepatic TRIM67 to obesity.

Citation

Chao Huang, Xiaoli Wei, Qihui Luo, Yu Xia, Ting Pan, Junbo He, Asad Jahangir, Lanlan Jia, Wentao Liu, Yuanfeng Zou, Lixia Li, Hongrui Guo, Yi Geng, Zhengli Chen. Loss of TRIM67 Attenuates the Progress of Obesity-Induced Non-Alcoholic Fatty Liver Disease. International journal of molecular sciences. 2022 Jul 05;23(13)