Clear Search sequence regions


  • adipogenesis (5)
  • chromatin (1)
  • fat brown (3)
  • heat (1)
  • mammals (3)
  • micrornas (1)
  • mrna transcripts (1)
  • rnas (5)
  • white fat (2)
  • Sizes of these terms reflect their relevance to your search.

    Long-chain noncoding RNAs (lncRNAs) are RNAs that do not code for proteins, widely present in eukaryotes. They regulate gene expression at multiple levels through different mechanisms at epigenetic, transcription, translation, and the maturation of mRNA transcripts or regulation of the chromatin structure, and compete with microRNAs for binding to endogenous RNA. Adipose tissue is a large and endocrine-rich functional tissue in mammals. Excessive accumulation of white adipose tissue in mammals can cause metabolic diseases. However, unlike white fat, brown and beige fats release energy as heat. In recent years, many lncRNAs associated with adipogenesis have been reported. The molecular mechanisms of how lncRNAs regulate adipogenesis are continually investigated. In this review, we discuss the classification of lncRNAs according to their transcriptional location. lncRNAs that participate in the adipogenesis of white or brown fats are also discussed. The function of lncRNAs as decoy molecules and RNA double-stranded complexes, among other functions, is also discussed.

    Citation

    Peiwen Zhang, Shuang Wu, Yuxu He, Xinrong Li, Yan Zhu, Xutao Lin, Lei Chen, Ye Zhao, Lili Niu, Shunhua Zhang, Xuewei Li, Li Zhu, Linyuan Shen. LncRNA-Mediated Adipogenesis in Different Adipocytes. International journal of molecular sciences. 2022 Jul 05;23(13)

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 35806493

    View Full Text