Catalytic Performance of Immobilized Sulfuric Acid on Silica Gel for N-Formylation of Amines with Triethyl Orthoformate.

Sodeeq Aderotimi Salami, Xavier Siwe-Noundou, Rui W M Krause

Molecules (Basel, Switzerland) 2022 Jun 30

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In the search for convenient, green, and practical catalytic methods for the current interest in organic synthesis, a simple, green, and highly efficient protocol for N-formylation of various amines was carried out in the presence of immobilized sulfuric acid on silica gel (H2SO4-SiO2). All reactions were performed in refluxing triethyl orthoformate (65 °C). The product formamides were obtained with high-to-excellent yields within 4 min to 2 h. The current approach is advantageous, due to its short reaction time and high yields. The catalyst is recyclable with no significant loss in catalytic efficiency.

Citation

Sodeeq Aderotimi Salami, Xavier Siwe-Noundou, Rui W M Krause. Catalytic Performance of Immobilized Sulfuric Acid on Silica Gel for N-Formylation of Amines with Triethyl Orthoformate. Molecules (Basel, Switzerland). 2022 Jun 30;27(13)