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    To date, there are no accepted soluble markers for disease activity and progression of neuromyelitis optica spectrum disorder (NMOSD). We aimed to evaluate longitudinal interleukin (IL)-6 levels in sera of NMOSD patients in correlation with disease activity and brain volume. We analyzed IL-6 serum levels of 26 NMOSD patients during relapse and remission. Significantly increased IL-6 levels were detected in patients with NMOSD during relapse. Furthermore, increased IL-6 levels correlated with relapse severity and brain atrophy. Our findings suggest that IL-6 serum level could serve as a biomarker for disease activity in NMOSD. Copyright © 2022. Published by Elsevier B.V.


    Adi Haramati, Ariel Rechtman, Omri Zveik, Nitzan Haham, Livnat Brill, Adi Vaknin-Dembinsky. IL-6 as a marker for NMOSD disease activity. Journal of neuroimmunology. 2022 Sep 15;370:577925

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    PMID: 35810527

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