Iron-Catalyzed Cycloisomerization and C-C Bond Activation to Access Non-canonical Tricyclic Cyclobutanes.

Cycloisomerizations are powerful skeletal rearrangements that allow the construction of complex molecular architectures in an atom-economic way. We present here an unusual type of cyclopropyl enyne cycloisomerization that couples the process of a cycloisomerization with the activation of a C-C bond in cyclopropanes. A set of substituted non-canonical tricyclic cyclobutanes were synthesized under mild conditions using [(Ph3 P)2 Fe(CO)(NO)]BF4 as catalyst in good to excellent yields with high levels of stereocontrol. © 2022 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.

Citation

Frederik Kramm, Franziska Ullwer, Benedict Klinnert, Min Zheng, Bernd Plietker. Iron-Catalyzed Cycloisomerization and C-C Bond Activation to Access Non-canonical Tricyclic Cyclobutanes. Angewandte Chemie (International ed. in English). 2022 Sep 19;61(38):e202205169

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PMID: 35818786

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