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Coat proteins (CPs) of RNA plant viruses play a pivotal role in virus particle assembly, vector transmission, host identification, RNA replication, and intracellular and intercellular movement. Numerous compounds targeting CPs have been designed, synthesized, and screened for their antiviral activities. This review is intended to fill a knowledge gap where a comprehensive summary is needed for antiviral agent discovery based on plant viral CPs. In this review, major achievements are summarized with emphasis on plant viral CPs as biochemical targets and action mechanisms of antiviral agents. This review hopefully provides new insights and references for the further development of new safe and effective antiviral pesticides.


Zilin Wu, Guangming Ma, Hengmin Zhu, Meiqing Chen, Min Huang, Xin Xie, Xiangyang Li. Plant Viral Coat Proteins as Biochemical Targets for Antiviral Compounds. Journal of agricultural and food chemistry. 2022 Jul 27;70(29):8892-8900

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PMID: 35830295

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