Correlation Engine 2.0
Clear Search sequence regions

  • alkyl (2)
  • catalysis (2)
  • cofactors (2)
  • enzymes (1)
  • MsrA (2)
  • redox (1)
  • reductases (2)
  • sulfoxides (8)
  • thio (1)
  • Sizes of these terms reflect their relevance to your search.

    Optically pure sulfoxides are noteworthy compounds applied in a wide range of industrial fields; however, the biocatalytic deracemization of racemic sulfoxides is challenging. Herein, a high-enantioselective methionine sulfoxide reductase A (MsrA) was combined with a low-enantioselective styrene monooxygenase (SMO) for the cyclic deracemization of sulfoxides. Enantiopure sulfoxides were obtained in >90 % yield and with >90 % enantiomeric excess (ee) through dynamic "selective reduction and non-selective oxidation" cycles. The cofactors of MsrA and SMO were subsequently regenerated by the cascade catalysis of three auxiliary enzymes through the consumption of low-cost D-glucose. Moreover, this "one-pot, one-step" cyclic deracemization strategy exhibited a wide substrate scope toward various aromatic, heteroaromatic, alkyl and thio-alkyl sulfoxides. This system proposed an efficient strategy for the green synthesis of chiral sulfoxide. © 2022 Wiley-VCH GmbH.


    Tao Peng, Jin Tian, Yuyan Zhao, Xu Jiang, Xiaoling Cheng, Guozhong Deng, Quan Zhang, Zhongqiang Wang, Jiawei Yang, Yongzheng Chen. Multienzyme Redox System with Cofactor Regeneration for Cyclic Deracemization of Sulfoxides. Angewandte Chemie (International ed. in English). 2022 Sep 12;61(37):e202209272

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 35831972

    View Full Text