Mechanistic insights and implications of FOXO-SNAI interplay.

Xiaowei Guo, Chenxi Wu, Yu Pan, Xiaojie Zhu, Kai Peng, Xianjue Ma, Lei Xue

BioEssays : news and reviews in molecular, cellular and developmental biology 2022 Sep

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Autophagy promotes both health and disease, depending on tissue types and genetic contexts, yet the regulatory mechanism remain incompletely understood. Our recent publication has uncovered a coherent FOXO-SNAI feed-forward loop in autophagy, which is evolutionarily conserved from Drosophila to human. In addition, it's revealed that DNA binding plays a critical role in intracellular localization of nucleocytoplasmic shuttling proteins. Based on these findings, herein we further integrate mechanistic insights of FOXO-SNAI regulatory interplay in autophagy and unravel the potential link of FOXO-induced autophagy with SNAI in diseases. Besides, the generality of DNA-retention mechanism on transcription factor nuclear localization is illustrated with wide-ranging discussion, and more functions potentially regulated by FOXO-SNAI feedforward loop are provided. Elucidation of these unsolved paradigms will expand the understanding of FOXO-SNAI interplay and facilitate the development of new therapeutics targeting FOXO-SNAI axis in diseases. © 2022 Wiley Periodicals LLC.

Citation

Xiaowei Guo, Chenxi Wu, Yu Pan, Xiaojie Zhu, Kai Peng, Xianjue Ma, Lei Xue. Mechanistic insights and implications of FOXO-SNAI interplay. BioEssays : news and reviews in molecular, cellular and developmental biology. 2022 Sep;44(9):e2200070