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    In the preceding chapter, we introduced bioluminescence-optogenetics (BL-OG) and luminopsin fusion proteins (LMOs), an emerging method of molecular neuromodulation. In addition to reviewing the fundamental principles of BL-OG, we provided a discussion of its application in vitro, including with cell lines and primary cells in culture in vitro. BL-OG is mediated by an easily diffusible molecule, luciferin, and when applied systemically in rodents, the substrate can spread throughout the body, including the brain, achieving powerful molecular neuromodulation with convenience even in awake and behaving animals. In this chapter, we provide a practical guide for BL-OG and LMO applications in rodent models of the nervous system, both ex vivo and in vivo. © 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.

    Citation

    Matthew A Stern, Henry Skelton, Alejandra M Fernandez, Claire-Anne N Gutekunst, Robert E Gross, Ken Berglund. Applications of Bioluminescence-Optogenetics in Rodent Models. Methods in molecular biology (Clifton, N.J.). 2022;2525:347-363

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    PMID: 35836082

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