Prevotella: An insight into its characteristics and associated virulence factors.

Geetika Sharma, Nancy Garg, Shamimul Hasan, Sheetal Shirodkar

Microbial pathogenesis 2022 Aug

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Prevotella species, a gram-negative obligate anaerobe, is commonly associated with human infections such as dental caries and periodontitis, as well as other conditions such as chronic osteomyelitis, bite-related infections, rheumatoid arthritis and intestinal diseases like ulcerative colitis. This generally harmless commensal possesses virulence factors such as adhesins, hemolysins, secretion systems exopolysaccharide, LPS, proteases, quorum sensing molecules and antibiotic resistance to evolve into a well-adapted pathogen capable of causing successful infection and proliferation in the host tissue. This review describes several of these virulence factors and their advantage to Prevotella spp. in causing inflammatory diseases like periodontitis. In addition, using genome analysis of Prevotella reference strains, we examined other putative virulence determinants which can provide insights as biomarkers and be the targets for effective interventions in Prevotella related diseases like periodontitis. Copyright © 2022 Elsevier Ltd. All rights reserved.

Citation

Geetika Sharma, Nancy Garg, Shamimul Hasan, Sheetal Shirodkar. Prevotella: An insight into its characteristics and associated virulence factors. Microbial pathogenesis. 2022 Aug;169:105673