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Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare inherited arrhythmogenic disorder induced by adrenergic stress. Electrophysiologically, it is characterized by emotional stress- or exercise-induced bidirectional ventricular tachycardia that may result in cardiac arrest. Minimizing perioperative stress is critical as it can reduce fatal arrhythmias in patients with CPVT. Dexmedetomidine (DEX), a centrally acting sympatholytic anesthetic agent, was used in the successful intravenous (IV) moderate sedation of a 27-year-old female patient with CPVT, a history of cardiac events, and significant dental fear and anxiety scheduled to undergo mandibular left third molar extraction. Oral surgery was successfully performed under DEX-based IV sedation to reduce stress, and no arrhythmias were observed. IV sedation with DEX provided a sympatholytic effect with respiratory and cardiovascular stability in this patient with CPVT who underwent oral surgery. © 2022 by the American Dental Society of Anesthesiology.


Yoshiki Shionoya, Kaoru Hirayama, Kaho Saito, Eriko Kawasaki, Yoko Kantake, Hazuki Okamoto, Takahiro Goi, Katsuhisa Sunada, Kiminari Nakamura. Anesthetic Management of a Patient With Catecholaminergic Polymorphic Ventricular Tachycardia. Anesthesia progress. 2022 Jun 01;69(2):24-29

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PMID: 35849806

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