HINGEneering IgG for enhanced immune activation.

Anja Werner, Falk Nimmerjahn

Science immunology 2022 Jul 15

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Two recent studies in Science Immunology by Orr et al. and Foss et al. demonstrate that the hinge region of immunoglobulin G (IgG) is a major regulator of IgG2 and IgG3 activity, respectively. Engineering of the IgG hinge may therefore be useful for optimizing the activity of IgG subclasses.