Two recent studies in Science Immunology by Orr et al. and Foss et al. demonstrate that the hinge region of immunoglobulin G (IgG) is a major regulator of IgG2 and IgG3 activity, respectively. Engineering of the IgG hinge may therefore be useful for optimizing the activity of IgG subclasses.
Anja Werner, Falk Nimmerjahn. HINGEneering IgG for enhanced immune activation. Science immunology. 2022 Jul 15;7(73):eabq4797
PMID: 35857582
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