Byung Joo Lee, Andrew R Ickes, Anil K Gupta, Seth C Ensign, Tam D Ho, Anika Tarasewicz, Evan P Vanable, Gregory D Kortman, Kami L Hull
Organic letters 2022 Aug 05Vicinal diamines are a common motif found in biologically active molecules. The hydroamination of allyl amine derivatives is a powerful approach for the synthesis of substituted 1,2-diamines. Herein, the rhodium-catalyzed hydroamination of primary and secondary allylic amines using diverse amine nucleophiles, including primary, secondary, acyclic, and cyclic aliphatic amines to access a wide range of unsymmetrical vicinal diamines, is presented. The utility of this methodology is further demonstrated through the rapid synthesis of several bioactive molecules and analogs.
Byung Joo Lee, Andrew R Ickes, Anil K Gupta, Seth C Ensign, Tam D Ho, Anika Tarasewicz, Evan P Vanable, Gregory D Kortman, Kami L Hull. Synthesis of Unsymmetrical Vicinal Diamines via Directed Hydroamination. Organic letters. 2022 Aug 05;24(30):5513-5518
PMID: 35862860
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