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CXCL9 and CXCL10 can be produced by antigen-presenting cells (dendritic cells or macrophages) and by tumor cells. Hoch et al. demonstrated that CXCL9 and CXCL10 co-localize with LAG3+ T cells expressing CCL4 or CXCL13 and contribute to the generation of a "hot" tumor microenvironment.
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Robin Reschke, Thomas F Gajewski. CXCL9 and CXCL10 bring the heat to tumors. Science immunology. 2022 Jul 22;7(73):eabq6509
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PMID: 35867802
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