Sphingolipids and their role in health and disease in the central nervous system.

Andrés Felipe Leal, Diego A Suarez, Olga Yaneth Echeverri-Peña, Sonia Luz Albarracín, Carlos Javier Alméciga-Díaz, Ángela Johana Espejo-Mojica

Advances in biological regulation 2022 Aug

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Sphingolipids (SLs) are lipids derived from sphingosine, and their metabolism involves a broad and complex network of reactions. Although SLs are widely distributed in the body, it is well known that they are present in high concentrations within the central nervous system (CNS). Under physiological conditions, their abundance and distribution in the CNS depend on brain development and cell type. Consequently, SLs metabolism impairment may have a significant impact on the normal CNS function, and has been associated with several disorders, including sphingolipidoses, Parkinson's, and Alzheimer's. This review summarizes the main SLs characteristics and current knowledge about synthesis, catabolism, regulatory pathways, and their role in physiological and pathological scenarios in the CNS. Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.

Citation

Andrés Felipe Leal, Diego A Suarez, Olga Yaneth Echeverri-Peña, Sonia Luz Albarracín, Carlos Javier Alméciga-Díaz, Ángela Johana Espejo-Mojica. Sphingolipids and their role in health and disease in the central nervous system. Advances in biological regulation. 2022 Aug;85:100900