Correlation Engine 2.0
Clear Search sequence regions

  • chancroid (1)
  • genes (1)
  • haemophilus ducreyi (3)
  • humans (4)
  • operon (2)
  • parent (1)
  • thus acid (1)
  • volunteers (1)
  • Sizes of these terms reflect their relevance to your search.

    Compared with wounded skin, ascorbic acid is enriched in pustules of humans experimentally infected with Haemophilus ducreyi. Compared with the broth-grown inocula, transcription of the H. ducreyi ulaABCD operon, which encodes genes for ascorbic acid uptake, is increased in pustules. We hypothesized that ascorbic acid uptake plays a role in H. ducreyi virulence. Five volunteers were infected with both H. ducreyi strain 35000HP and its isogenic ulaABCD deletion mutant at multiple sites; the papule and pustule formation rates of the mutant and parent strains were similar. Thus, ascorbic acid uptake is not essential for H. ducreyi virulence in humans. The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail:


    Julie A Brothwell, Kate R Fortney, Teresa Batteiger, Barry P Katz, Stanley M Spinola. Dispensability of Ascorbic Acid Uptake and Utilization Encoded by ulaABCD for the Virulence of Haemophilus ducreyi in Humans. The Journal of infectious diseases. 2023 Feb 01;227(3):317-321

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 35876728

    View Full Text