Correlation Engine 2.0
Clear Search sequence regions


  • blood (1)
  • bone (3)
  • cardiovascular diseases (1)
  • CLC 7 (1)
  • Ctsk (1)
  • diseases and (1)
  • duodenum (2)
  • effects drugs (1)
  • femur (1)
  • FPN1 (1)
  • hepcidin (4)
  • homeostasis (1)
  • iron (13)
  • liver (3)
  • osteoblast (1)
  • osteoclast (2)
  • prazosin (11)
  • research (1)
  • serum (1)
  • shrs rats (3)
  • spleen (1)
  • TLR4 (1)
  • wistar- kyoto rats (4)
  • Sizes of these terms reflect their relevance to your search.

    The relationship between cardiovascular diseases and iron disorders has gained increasing attention; however, the effects of hypotensive drugs on iron metabolic alterations in hypertension are not well understood. The purpose of this study was to investigate iron metabolic changes after prazosin treatment of spontaneously hypertensive rats (SHRs) and Wistar-Kyoto (WKY) rats. Our second objective was to examine the effects of hypertension and anti-hypertensive drugs on bone formation and resorption. SHRs and WKY rats were randomized into either prazosin-treated groups (WKY + PZ and SHR + PZ) or untreated groups (WKY and SHR). After 7 days of intragastric prazosin administration, the rats were sacrificed for analysis; blood samples and organs (the duodenum, liver, kidneys, spleen, and femur) were collected. Both WKY + PZ and SHR groups exhibited iron deficiency in the serum and liver. Prazosin increased the iron levels in the bone tissue of SHRs. Prazosin stimulated the expression of hepcidin mRNA in the liver of SHRs and inhibited the expression of this iron-regulatory hormone in WKY rats. FPN1 expression in the duodenum was increased significantly in SHRs, however markedly decreased after prazosin treatment. The expression of TLR4 and Ctsk was enhanced in the bone tissue of SHRs, whereas CLC-7 expression was inhibited. Both hypotension and hypertension can lead to iron deficiency. Treatment with prazosin restored iron homeostasis in SHRs. The inverse impacts of prazosin on hepatic hepcidin expression in SHRs versus WKY rats indicates differing iron regulatory mechanisms between hypertensive and normal animals. The osteoclast activity was found to be enhanced in SHRs. Further study is needed to address whether the changes in osteoblast and osteoclast activity in SHRs correlates with the effects on iron metabolism. © 2022 The Authors. Pharmacology Research & Perspectives published by British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics and John Wiley & Sons Ltd.

    Citation

    Hengrui Chang, Dong Zhang, Zhen Xin, Pengfei Zhang, Wenyuan Ding, Yan-Zhong Chang. Influence of prazosin on systemic iron levels and the associated iron metabolic alterations in spontaneously hypertensive rats. Pharmacology research & perspectives. 2022 Aug;10(4):e00991

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 35892277

    View Full Text