Correlation Engine 2.0
Clear Search sequence regions

  • afadin (1)
  • bind proteins (1)
  • female (1)
  • human (2)
  • listeria (20)
  • listeriosis (2)
  • pathogenesis (2)
  • placenta (2)
  • pregnancy (1)
  • pregnant women (1)
  • rich (1)
  • tropism (1)
  • Sizes of these terms reflect their relevance to your search.

    Listeria monocytogenes (Lm) is a bacterial pathogen that causes listeriosis in immunocompromised individuals, particularly pregnant women. Several virulence factors support the intracellular lifecycle of Lm and facilitate cell-to-cell spread, allowing it to occupy multiple niches within the host and cross-protective barriers, including the placenta. One family of virulence factors, internalins, contributes to Lm pathogenicity by inducing specific uptake and conferring tissue tropism. Over 25 internalins have been identified thus far, but only a few have been extensively studied. Internalins contain leucine-rich repeat (LRR) domains that enable protein-protein interactions, allowing Lm to bind host proteins. Notably, other Listeria species express internalins but cannot colonize human hosts, prompting questions regarding the evolution of internalins within the genus Listeria. Internalin P (InlP) promotes placental colonization through interaction with the host protein afadin. Although prior studies of InlP have begun to elucidate its role in Lm pathogenesis, there remains a lack of information regarding homologs in other Listeria species. Here, we have used a computational evolutionary approach to identify InlP homologs in additional Listeria species. We found that Listeria ivanovii londoniensis (Liv) and Listeria seeligeri (Ls) encode InlP homologs. We also found InlP-like homologs in Listeria innocua and the recently identified species Listeria costaricensis. All newly identified homologs lack the full-length LRR6 and LRR7 domains found in Lm's InlP. These findings are informative regarding the evolution of one key Lm virulence factor, InlP, and serve as a springboard for future evolutionary studies of Lm pathogenesis as well as mechanistic studies of Listeria internalins.


    Kayla N Conner, Joseph T Burke, Janani Ravi, Jonathan W Hardy. Novel internalin P homologs in Listeria. Microbial genomics. 2022 Jul;8(7)

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 35904424

    View Full Text