TFE3 Rearrangement and Expression in Renal Cell Carcinoma.

Michel Kmeid, Mahmut Akgul

International journal of surgical pathology 2023 Aug

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TFE3 rearranged Renal cell carcinoma (RCC) is not very common, and demonstrates unique heterogenous morphological features overlapping other recognized entities and distinct immunoprofile. It can be seen in any age group, therefore practicing pathologists should be aware of the distinctive clinical settings and histologic findings associated with these tumors and subsequently employ an adequate panel of ancillary studies in order to confirm the diagnosis. Recognizing these entities remains crucial for future clinical trials and development of novel therapies.

Citation

Michel Kmeid, Mahmut Akgul. TFE3 Rearrangement and Expression in Renal Cell Carcinoma. International journal of surgical pathology. 2023 Aug;31(5):509-520