Correlation Engine 2.0
Clear Search sequence regions

  • ethanol (2)
  • female (1)
  • humans (1)
  • men (1)
  • social drinkers (3)
  • students (1)
  • ventral striatum (3)
  • women (1)
  • Sizes of these terms reflect their relevance to your search.

    Alcohol craving is an urge to consume alcohol that commonly precedes drinking; however, craving does not lead to drinking for all people under all circumstances. The current study measured the correlation between neural reactivity and alcohol cues as a risk, and purpose in daily life as a protective factor that may influence the link between alcohol craving and the subsequent amount of consumption. Observational study that correlated functional magnetic resonance imaging (fMRI) data on neural cue reactivity and ecological momentary assessments (EMA) on purpose in life and alcohol use. Two college campuses in the United States. A total of 54 college students (37 women, 16 men, and 1 other) recruited via campus-based groups from January 2019 to October 2020. Participants underwent fMRI while viewing images of alcohol; we examined activity within the ventral striatum, a key region of interest implicated in reward and craving. Participants then completed 28 days of EMA and answered questions about daily levels of purpose in life and alcohol use, including how much they craved and consumed alcohol. A significant three-way interaction indicated that greater alcohol cue reactivity within the ventral striatum was associated with heavier alcohol use following craving in daily life only when people were previously feeling a lower than usual sense of purpose. By contrast, individuals with heightened neural alcohol cue reactivity drank less in response to craving if they were feeling a stronger than their usual sense of purpose in the preceding moments (binteraction  = -0.086, P < 0.001, 95% CI = -0.137, -0.035). Neural sensitivity to alcohol cues within the ventral striatum appears to be a potential risk for increased alcohol use in social drinkers, when people feel less purposeful. Enhancing daily levels of purpose in life may promote alcohol moderation among social drinkers who show relatively higher reactivity to alcohol cues. © 2022 Society for the Study of Addiction.


    Yoona Kang, Danielle Cosme, David Lydon-Staley, Jeesung Ahn, Mia Jovanova, Faustine Corbani, Silicia Lomax, Ovidia Stanoi, Victor Strecher, Peter J Mucha, Kevin Ochsner, Dani S Bassett, Emily B Falk. Purpose in life, neural alcohol cue reactivity and daily alcohol use in social drinkers. Addiction (Abingdon, England). 2022 Dec;117(12):3049-3057

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 35915548

    View Full Text