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Kinugasa Reaction for DNA-Encoded β-Lactam Library Synthesis.
Ayun Luo, Ziqi Zhang, Fanming Zeng, Xiuming Wang, Xue Zhao, Kexin Yang, Yun Jin Hu
Organic letters 2022 Aug 12Sizes of these terms reflect their relevance to your search.
β-Lactam antibiotics are one of the most important antibacterial drug classes worldwide. This work will present the first prototype on-DNA β-lactam combinatorial library with novel structures and chemical space properties that would be significant for phenotypic screening to identify the next generation of antibiotics to combat the pervasive problem of bacterial resistance.
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Ayun Luo, Ziqi Zhang, Fanming Zeng, Xiuming Wang, Xue Zhao, Kexin Yang, Yun Jin Hu. Kinugasa Reaction for DNA-Encoded β-Lactam Library Synthesis. Organic letters. 2022 Aug 12;24(31):5756-5761
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PMID: 35916753
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