Synthesis, photophysical properties and photo-induced cytotoxicity of novel tris(diazatriphenylene)ruthenium (II) complex.

Srinivas Samala, Woojeong Lim, Dong Kyun You, Kang Mun Lee, Hongil Jo, Kang Min Ok, Jongmin Park, Chang-Hee Lee

Bioorganic chemistry 2022 Nov

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Novel bipyridine-based heterocyclic building block, 3,10-dichloro-benzo[f][1,10]phenanthroline and its Ruthenium(II) complex have been synthesized and fully characterized. The synthesized Ru(II)-complex is highly luminescent displaying emission at 590 nm with quantum yield of ∼0.8 in methanol. Ru(II) complex showed photocytotoxicity upon 400 nm blue light irradiation. Mechanistic study revealed that photoactivated Ru(II) complex generates reactive radical species which can damage the protein inside the cells and induce cell death even with short irradiation time. Copyright © 2022 Elsevier Inc. All rights reserved.

Citation

Srinivas Samala, Woojeong Lim, Dong Kyun You, Kang Mun Lee, Hongil Jo, Kang Min Ok, Jongmin Park, Chang-Hee Lee. Synthesis, photophysical properties and photo-induced cytotoxicity of novel tris(diazatriphenylene)ruthenium (II) complex. Bioorganic chemistry. 2022 Nov;128:106044