Noaoxazole, a new heat shock metabolite produced by thermotolerant Streptomyces sp. HR41.

Shun Saito, Shiina Suzuki, Midori A Arai

The Journal of antibiotics 2022 Sep

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The thermotolerant strain Streptomyces sp. HR41 was found to produce compound 1 only in a 45 °C culture, and not at the standard temperature. We previously designated this type of compound as a "heat shock metabolite" (HSM). NMR and MS analytical techniques were used to determine that the chemical structure of 1 comprised a methylated-oxazole ring and a linear chain moiety modified with a terminal amide group. Thus, 1 was shown to be a new curromycin analog, which we have designated noaoxazole (1). Compound 1 weakly activated Notch signal reporter activity without exhibiting cytotoxicity against assay cells at the same concentration. © 2022. The Author(s), under exclusive licence to the Japan Antibiotics Research Association.

Citation

Shun Saito, Shiina Suzuki, Midori A Arai. Noaoxazole, a new heat shock metabolite produced by thermotolerant Streptomyces sp. HR41. The Journal of antibiotics. 2022 Sep;75(9):509-513