Two new antimicrobial monoterpenoid indole alkaloids from the roots of Rauvolfia yunnanensis.

Two new monoterpenoid indole alkaloids 3-hydroxylochnerine (1) and 10-hydroxyvinorine (2) were isolated from the roots of Rauvolfia yunnanensis. Their structures were elucidated based on the analysis of spectroscopic data and ECD calculation. Both compounds exhibited potent antimicrobial activity against Bacillus subtilis and Escherichia coli, and their activities were comparable to the well-known antibacterial drug berberine.

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Wu Hao, Qin Ma-Long, Fan Kun, Gao Wen, Guo Rui-Rong, Yin Shan-Ze, Hu Wei-Yan, Zhang Lan-Chun, Zhang Rong-Ping, Yu Hao-Fei, Li Yu-Peng, Ding Cai-Feng. Two new antimicrobial monoterpenoid indole alkaloids from the roots of Rauvolfia yunnanensis. Journal of Asian natural products research. 2023 May;25(5):429-437

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PMID: 35930443

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