Human colonic catabolism of dietary flavan-3-ol bioactives.

Giuseppe Di Pede, Pedro Mena, Letizia Bresciani, Tahani M Almutairi, Daniele Del Rio, Michael N Clifford, Alan Crozier

Molecular aspects of medicine 2023 Feb

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Understanding the fate of ingested polyphenols is crucial in elucidating the molecular mechanisms underlying the beneficial effects of a fruit and vegetable-based diet. This review focuses on the colon microbiota-mediated transformation of the flavan-3-ols and the structurally related procyanidins found in dietary plant foods and beverages, plus the flavan-3-ol-derived theaflavins of black tea, and the post-absorption phase II metabolism of the gut microbiota catabolites. Despite significant advances in the last decade major analytical challenges remain. Strategies to address them are presented. Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.

Citation

Giuseppe Di Pede, Pedro Mena, Letizia Bresciani, Tahani M Almutairi, Daniele Del Rio, Michael N Clifford, Alan Crozier. Human colonic catabolism of dietary flavan-3-ol bioactives. Molecular aspects of medicine. 2023 Feb;89:101107