Hypocholesterolemic action of 1-ethoxysilatrane.

Intraperitoneal administration of the organosilicon compound 1-ethoxysilatrane to the rat caused a 25% decrease in the concentration of cholesterol in serum without affecting that of triacylglycerols. The specific activity of 3-hydroxy-3-methylglutaryl CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis, was depressed in hepatic microsomes of silatrane-treated animals.

Citation

P P Mehta, T Ramasarma, C K Kurup. Hypocholesterolemic action of 1-ethoxysilatrane. Biochimica et biophysica acta. 1987 Jul 13;920(1):102-4

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PMID: 3593753

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