Long-term effects of Pfizer-BioNTech COVID-19 vaccinations on platelets.

Cytometry. Part A : the journal of the International Society for Analytical Cytology 2023 Feb

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There is a global concern about the safety of COVID-19 vaccines associated with platelet function. However, their long-term effects on overall platelet activity remain poorly understood. Here we address this problem by image-based single-cell profiling and temporal monitoring of circulating platelet aggregates in the blood of healthy human subjects, before and after they received multiple Pfizer-BioNTech (BNT162b2) vaccine doses over a time span of nearly 1 year. Results show no significant or persisting platelet aggregation trends following the vaccine doses, indicating that any effects of vaccinations on platelet turnover, platelet activation, platelet aggregation, and platelet-leukocyte interaction was insignificant. © 2022 International Society for Advancement of Cytometry.

Citation

Yuqi Zhou, Masako Nishikawa, Hiroshi Kanno, Ruoxi Yang, Yuma Ibayashi, Ting-Hui Xiao, Walker Peterson, Maik Herbig, Nao Nitta, Shigeki Miyata, Yogendra Kanthi, Gustavo K Rohde, Kyoji Moriya, Yutaka Yatomi, Keisuke Goda. Long-term effects of Pfizer-BioNTech COVID-19 vaccinations on platelets. Cytometry. Part A : the journal of the International Society for Analytical Cytology. 2023 Feb;103(2):162-167