Correlation Engine 2.0
Clear Search sequence regions

  • blood flow (2)
  • brain (10)
  • humans (1)
  • hypoxia (1)
  • injuries (2)
  • ischemia (2)
  • oxygen (1)
  • patients (1)
  • traumatic (6)
  • Sizes of these terms reflect their relevance to your search.

    Outcome following traumatic brain injury (TBI) remains variable, and derangements in cerebral metabolism are a common finding in patients with poor outcome. This review compares our understanding of cerebral metabolism in health with derangements seen following TBI. Ischemia is common within the first 24 h of injury and inconsistently detected by bedside monitoring. Metabolic derangements can also result from tissue hypoxia in the absence of ischemic reductions in blood flow due to microvascular ischemia and mitochondrial dysfunction. Glucose delivery across the injured brain is dependent on blood glucose and regional cerebral blood flow, and is an important contributor to derangements in glucose metabolism. Alternative energy substrates such as lactate, ketone bodies and succinate that may support mitochondrial function, and can be utilized when glucose availability is low, have been studied following TBI but require further investigation. Mitochondrial dysfunction and the use of alternative energy substrates are potential therapeutic targets, but improved understanding of the causes, impact and significance of metabolic derangements in clinical TBI are needed. Maintaining adequate oxygen and glucose delivery across the injured brain may accelerate the recovery of mitochondrial function and cerebral energy metabolism and remain important management targets. Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc.


    Simon Demers-Marcil, Jonathan P Coles. Cerebral metabolic derangements following traumatic brain injury. Current opinion in anaesthesiology. 2022 Oct 01;35(5):562-569

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 35943124

    View Full Text