Proteomic saliva assay in patients with COVID-19].

O O Yanuchevish, I V Mayev, E A Karton, I G Ostrovskaya

Stomatologiia 2022

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Was to perform proteomic saliva assay in order to reveal mechanisms of the oral pathology caused by COVID-19. Proteomic analysis was performed to compare saliva proteins profile in healthy individuals (10 samples) and patients with COVID-19 (30 samples). The obtained results of the saliva samples study in patients with COVID-19 indicate activation in the oral tissues the pathways of the cell renewal, apoptosis, DNA exchange processes and chromatin remodelling; there are also marked signs of immune response reactivation and immunostimulation. Of all the proteins presented, the saliva of patients with COVID-19 33 proteins have an intersection with GO-annotated proteins of inflammation and epithelial cornification.