The Kv10.1 Channel: A Promising Target in Cancer.

Enoch Luis, Arely Anaya-Hernández, Paulina León-Sánchez, María Luisa Durán-Pastén

International journal of molecular sciences 2022 Jul 30

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Carcinogenesis is a multistage process involving the dysregulation of multiple genes, proteins, and pathways that make any normal cell acquire a cancer cell phenotype. Therefore, it is no surprise that numerous ion channels could be involved in this process. Since their discovery and subsequent cloning, ion channels have been established as therapeutic targets in excitable cell pathologies (e.g., cardiac arrhythmias or epilepsy); however, their involvement in non-excitable cell pathologies is relatively recent. Among all ion channels, the voltage-gated potassium channels Kv10.1 have been established as a promising target in cancer treatment due to their high expression in tumoral tissues compared to low levels in healthy tissues.

Citation

Enoch Luis, Arely Anaya-Hernández, Paulina León-Sánchez, María Luisa Durán-Pastén. The Kv10.1 Channel: A Promising Target in Cancer. International journal of molecular sciences. 2022 Jul 30;23(15)