Anti-Pulmonary Fibrosis Activities of Triterpenoids from Oenothera biennis.

Juanjuan Liu, Jingke Zhang, Mengnan Zeng, Meng Li, Shuangshuang Xie, Xiaoke Zheng, Weisheng Feng

Molecules (Basel, Switzerland) 2022 Jul 29

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Five new triterpenoids, oenotheralanosterols C-G (1-5), with seven known triterpenoidcompounds, namely 2α,3α,19α-trihydroxy-24-norurs4,12-dien-28-oic acid (6), 3β,23-dihydroxy-1-oxo-olean-12-en-28-oic acid (7), remangilone C (8), knoxivalic acid A (9), termichebulolide (10), rosasecotriterpene A (11), androsanortriterpene C (12), were extracted and separated from the dichloromethane part of Oenothera biennis L. The anti-pulmonary fibrosis activities of all the compounds against TGF-β1-induced damage tonormal human lung epithelial (BEAS-2B) cells were investigated in vitro. The results showed that compounds 1-2, 6, 8, and 11 exhibited significant anti-pulmonary fibrosis activities, with EC50 values ranging from 4.7 μM to 9.9 μM.

Citation

Juanjuan Liu, Jingke Zhang, Mengnan Zeng, Meng Li, Shuangshuang Xie, Xiaoke Zheng, Weisheng Feng. Anti-Pulmonary Fibrosis Activities of Triterpenoids from Oenothera biennis. Molecules (Basel, Switzerland). 2022 Jul 29;27(15)