Muhammad Zafar Irshad Khan, Muhammad Uzair, Adila Nazli, Jian-Zhong Chen
European journal of medicinal chemistry 2022 Nov 05Estrogen governs the regulations of various pathological and physiological actions throughout the body in both males and females. Generally, 17β-estradiol an endogenous estrogen is responsible for different health problems in pre and postmenopausal women. The major activities of endogenous estrogen are executed by nuclear estrogen receptors (ERs) ERα and ERβ while non-genomic cytoplasmic pathways also govern cell growth and apoptosis. Estrogen accomplished a fundamental role in the formation and progression of breast cancer. In this review, we have hyphenated different studies regarding ERs and a thorough and detailed study of estrogen receptors is presented. This review highlights different aspects of estrogens ranging from receptor types, their isoforms, structures, signaling pathways of ERα, ERβ and GPER along with their crystal structures, pathological roles of ER, ER ligands, and therapeutic strategies to overcome the resistance. Copyright © 2022 Elsevier Masson SAS. All rights reserved.
Muhammad Zafar Irshad Khan, Muhammad Uzair, Adila Nazli, Jian-Zhong Chen. An overview on Estrogen receptors signaling and its ligands in breast cancer. European journal of medicinal chemistry. 2022 Nov 05;241:114658
PMID: 35964426
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