Peptide Centric Vβ Specific Germline Contacts Shape a Specialist T Cell Response.

Yang Wang, Alexandra Tsitsiklis, Stephanie Devoe, Wei Gao, H Hamlet Chu, Yan Zhang, Wei Li, Wing Ki Wong, Charlotte M Deane, David Neau, Jill E Slansky, Paul G Thomas, Ellen A Robey, Shaodong Dai

Frontiers in immunology 2022

filter terms:

Certain CD8 T cell responses are particularly effective at controlling infection, as exemplified by elite control of HIV in individuals harboring HLA-B57. To understand the structural features that contribute to CD8 T cell elite control, we focused on a strongly protective CD8 T cell response directed against a parasite-derived peptide (HF10) presented by an atypical MHC-I molecule, H-2Ld. This response exhibits a focused TCR repertoire dominated by Vβ2, and a representative TCR (TG6) in complex with Ld-HF10 reveals an unusual structure in which both MHC and TCR contribute extensively to peptide specificity, along with a parallel footprint of TCR on its pMHC ligand. The parallel footprint is a common feature of Vβ2-containing TCRs and correlates with an unusual Vα-Vβ interface, CDR loop conformations, and Vβ2-specific germline contacts with peptides. Vβ2 and Ld may represent "specialist" components for antigen recognition that allows for particularly strong and focused T cell responses. Copyright © 2022 Wang, Tsitsiklis, Devoe, Gao, Chu, Zhang, Li, Wong, Deane, Neau, Slansky, Thomas, Robey and Dai.

Citation

Yang Wang, Alexandra Tsitsiklis, Stephanie Devoe, Wei Gao, H Hamlet Chu, Yan Zhang, Wei Li, Wing Ki Wong, Charlotte M Deane, David Neau, Jill E Slansky, Paul G Thomas, Ellen A Robey, Shaodong Dai. Peptide Centric Vβ Specific Germline Contacts Shape a Specialist T Cell Response. Frontiers in immunology. 2022;13:847092