Microdistribution of internal radiation dose in biological tissues exposed to 56Mn dioxide microparticles.

Journal of radiation research 2022 Aug 13

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Manganese-56 (56Mn) was one of the dominant neutron-activated radionuclides during the first hours following the atomic-bombing of Hiroshima and Nagasaki. The radiation spectrum of 56Mn and the radiation emission from excited levels of 56Fe following 56Mn beta-decay include gamma-quanta, beta-particles, Auger electrons and X-rays. The dispersion of neutron activated 56Mn in the air can lead to entering of radioactive microparticles into the lungs. The investigation of spatial microdistribution of an internal dose in biological tissue exposed to 56Mn is an important matter with regards to the possible elevated irradiation of the lung alveoli and alveolar ducts. The Monte Carlo code (MCNP-4C) was used for the calculation of absorbed doses in biological tissue around 56Mn dioxide microparticles. The estimated absorbed dose has a very essential gradient in the epithelium cells of lung alveoli and alveolar duct: from 61 mGy/decay on the surface of simple squamous cells of epithelium to 0.15 mGy/decay at distance of 0.3 μm, which is maximal cell thickness. It has been concluded that epithelial cells of these pulmonary microstructures are selectively irradiated by low-energy electrons: short-range component of beta-particles spectrum and Auger electrons. The data obtained are important for the interpretation of biological experiments implementing dispersed neutron-activated 56Mn dioxide powder. © The Author(s) 2022. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Citation

Valeriy Stepanenko, Andrey Kaprin, Sergey Ivanov, Peter Shegay, Viktoria Bogacheva, Hitoshi Sato, Kazuko Shichijo, Shin Toyoda, Noriyuki Kawano, Megu Ohtaki, Nariaki Fujimoto, Satoru Endo, Nailya Chaizhunusova, Dariya Shabdarbaeva, Kassym Zhumadilov, Masaharu Hoshi. Microdistribution of internal radiation dose in biological tissues exposed to 56Mn dioxide microparticles. Journal of radiation research. 2022 Aug 13;63(Supplement_1):i21-i25