Site-selective C-H alkylation of myo-inositol via organic photoredox catalysis.

Haonan Cao, Tianyun Guo, Xuemei Deng, Xing Huo, Shouchu Tang, Jian Liu, Xiaolei Wang

Chemical communications (Cambridge, England) 2022 Sep 01

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Site-selective photoredox reactions with aromatic olefins enable direct alkylation of unprotected myo-inositol at C4. The efficacy of these reactions can be finely tuned by modifying the structures of HAT reagents. These reactions open the possibility of selective C-H alkylations of myo-inositol without the need for multi-step protection-deprotection strategies.

Citation

Haonan Cao, Tianyun Guo, Xuemei Deng, Xing Huo, Shouchu Tang, Jian Liu, Xiaolei Wang. Site-selective C-H alkylation of myo-inositol via organic photoredox catalysis. Chemical communications (Cambridge, England). 2022 Sep 01;58(71):9934-9937