Alparslan Köhle, Arif Gülkesen, Tuba Kaya Karataş, Gürkan Akgöl, Ahmet Karataş, Necip İlhan, Süleyman Serdar Koca
Turkish journal of physical medicine and rehabilitation 2022 JunThis study aims to define serum levels of netrin-1 and netrin receptors in patients with fibromyalgia (FM) and osteoarthritis (OA). This cross-sectional study was conducted with a total of 150 female participants (mean age: 47.2±16.1 years; range, 18 to 89 years) at Fırat University between June 2016 and December 2016. The participants were evaluated in three groups: the FM group with 50 patients, the OA group with 50 patients, and the control group, which included 50 healthy volunteers. Netrin-1, netrin receptors (DCC, UNC5B, and UNC5D), interleukin (IL)-6, IL-10, and IL-17 levels were analyzed by the enzyme-linked immunosorbent assay from the serum samples of the participants. The level of serum netrin-1 was significantly lower in the FM group than in the control and OA groups (p<0.01 and p<0.001, respectively). However, the difference between patients with OA and healthy controls in terms of netrin-1 was not statistically significant (p>0.05). In addition, serum levels of netrin receptors and cytokines in the FM group were similar to the control group (p>0.05). However, serum DCC, UNC5D, IL-6, and IL-10 levels were higher in the OA group compared to the control group (p<0.001, p<0.05, p<0.01, and p<0.001, respectively). Serum netrin-1 level is suppressed in FM, which suggests that netrin-1 is influential in FM pathogenesis. Copyright © 2022, Turkish Society of Physical Medicine and Rehabilitation.
Alparslan Köhle, Arif Gülkesen, Tuba Kaya Karataş, Gürkan Akgöl, Ahmet Karataş, Necip İlhan, Süleyman Serdar Koca. Serum netrin-1 and netrin receptor levels in fibromyalgia and osteoarthritis. Turkish journal of physical medicine and rehabilitation. 2022 Jun;68(2):238-245
PMID: 35989959
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